Phenolic acids improve the antioxidant activity of ceruloplasmin isolated from plasma of healthy volunteers and patients

Bogna Gryszczyńska , Maria Iskra , Tomasz Wielkoszyński , Maria Małecka , Magdalena Budzyń-Napierała , Magdalena Kasprzak , Agnieszka Gryszczyńska

Abstract

The aim of the present study was to estimate the ability of individual phenolic acids to eliminate Fe(II) ions from the solution. Moreover, the influence of phenolic acids on the ferroxidase activity of ceruloplasmin (Cp) isolated from blood plasma of healthy volunteers (CpC) and patients with atherosclerosis obliterans (CpAO) was established in vitro. Phenolic acids demonstrated a ferroxidase-like activity, i.e. the ability to eliminate Fe(II) ions, within the studied concentration range of 2.0-17.0 mol•10-5dm-3, in the following order of decreasing effectiveness: caffeic acid (CA)>ellagic acid (EA)>chlorogenic acid (ChA)>ferulic acid (FA) ≈ p-coumaric acid (PcA) = sinapic acid (SA). The study showed that the ability of phenolic acids to eliminate Fe(II) ions by oxidation or chelation was related to the structure of the former, to the presence of orto-OH groups, especially. Furthermore, the effect of the molar ratio of phenolic acid to Fe(II) ion was observed. EA and ChA, both containing two orto-OH groups and the highest number of –OH groups (4 and 5, respectively), demonstrated the greatest ability to eliminate Fe(II) ions, especially at the Fe(II) to phenolic acid molar ratio of 6:1. Phenolic acids added to samples with a constant amount of Cp caused decrease in the concentration of Fe(II) ions. Therefore, it may be assumed that the addition of phenolic acids to CpC and CpAO, even in low concentrations, caused a significant decrease in the concentration of Fe(II) ions.
Author Bogna Gryszczyńska - Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Bogna Gryszczyńska,,
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, Maria Iskra - Poznań University of Medical Sciences
Maria Iskra,,
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, Tomasz Wielkoszyński - Śląska Akademia Medyczna w Zabrzu
Tomasz Wielkoszyński,,
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, Maria Małecka (WT / KTAS)
Maria Małecka,,
- Department of Food Commodity Science
, Magdalena Budzyń-Napierała
Magdalena Budzyń-Napierała,,
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, Magdalena Kasprzak
Magdalena Kasprzak,,
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, Agnieszka Gryszczyńska
Agnieszka Gryszczyńska,,
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Journal seriesJournal of Elementology, ISSN 1644-2296, (A 15 pkt)
Issue year2015
Vol20
No1
Pages83-93
Publication size in sheets0.5
Keywords in Englishcaffeic acid, chlorogenic acid, ellagic acid, ferulic acid, sinapic acid, p-coumaric acid, atherosclerosis obliterans, ceruloplasmin, ferroxidase activity
ASJC Classification2307 Health, Toxicology and Mutagenesis; 1604 Inorganic Chemistry; 2310 Pollution; 2303 Ecology
DOIDOI:10.5601/jelem.2014.19.3.501
URL http://www.uwm.edu.pl/jold/index.2012015.pdf
Languageen angielski
Score (nominal)15
Score sourcejournalList
ScoreMinisterial score = 15.0, 15-08-2020, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 15-08-2020, ArticleFromJournal
Publication indicators WoS Citations = 3; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 0.75; WoS Impact Factor: 2015 = 0.719 (2) - 2015=0.779 (5)
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