Antifungal Activity of Morpholine and Piperidine Based Surfactants

Daria Wieczorek , Dobrawa Kwaśniewska , Li-Hang Hsu , Tang-Long Shen , Ying-Lien Chen


Microorganisms have the remarkable capacity to develop resistance to antimicrobial agents. This is of particular concern for fungal pathogens which cause devastating invasive infections with limited treatment options. Thus the need for new antifungal agents is undeniable. This work presents the antifungal properties of four surfactant groups, namely two groups of sulfobetaines and two groups of quaternary ammonium compounds, all morpholine and piperidine derivatives, against drug susceptible or drug resistant Candida albicans and Cryptococcus neoformans. The values of minimum inhibitory and fungicidal concentrations were determined. As follows from the results, the activities of the obtained compounds differed, however the most active agents from each homologous series of compounds, such as P16S3, P16S4 and C16S3, were pointed out.
Author Daria Wieczorek (WT / KTiAI)
Daria Wieczorek,,
- Department of Technology and Instrumental Analysis
, Dobrawa Kwaśniewska (WT / KTiAI)
Dobrawa Kwaśniewska,,
- Department of Technology and Instrumental Analysis
, Li-Hang Hsu
Li-Hang Hsu,,
, Tang-Long Shen - National Taiwan University
Tang-Long Shen ,,
, Ying-Lien Chen - National Taiwan University
Ying-Lien Chen ,,
Journal seriesTenside Surfactants Detergents, [Tenside, Surfactants, Detergents], ISSN 0932-3414, (N/A 40 pkt)
Issue year2020
Publication size in sheets0.5
Keywords in Polishsulfobetainy, surfaktanty, aktywność przeciwgrzybicza
Keywords in EnglishSulfobetaines, surfactants, antifungal activity
ASJC Classification1500 General Chemical Engineering; 1600 General Chemistry; 3104 Condensed Matter Physics
Languageen angielski
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 24-07-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.487; WoS Impact Factor: 2018 = 0.748 (2) - 2018=0.799 (5)
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