Antifungal Activity of Morpholine and Piperidine Based Surfactants
Daria Wieczorek , Dobrawa Kwaśniewska , Li-Hang Hsu , Tang-Long Shen , Ying-Lien Chen
AbstractMicroorganisms have the remarkable capacity to develop resistance to antimicrobial agents. This is of particular concern for fungal pathogens which cause devastating invasive infections with limited treatment options. Thus the need for new antifungal agents is undeniable. This work presents the antifungal properties of four surfactant groups, namely two groups of sulfobetaines and two groups of quaternary ammonium compounds, all morpholine and piperidine derivatives, against drug susceptible or drug resistant Candida albicans and Cryptococcus neoformans. The values of minimum inhibitory and fungicidal concentrations were determined. As follows from the results, the activities of the obtained compounds differed, however the most active agents from each homologous series of compounds, such as P16S3, P16S4 and C16S3, were pointed out.
|Journal series||Tenside Surfactants Detergents, [Tenside, Surfactants, Detergents], ISSN 0932-3414, (N/A 40 pkt)|
|Publication size in sheets||0.5|
|Keywords in Polish||sulfobetainy, surfaktanty, aktywność przeciwgrzybicza|
|Keywords in English||Sulfobetaines, surfactants, antifungal activity|
|ASJC Classification||; ;|
|Score||= 40.0, 30-06-2020, ArticleFromJournal|
|Publication indicators||: 2016 = 0.487; : 2018 = 0.748 (2) - 2018=0.799 (5)|
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