Evaluation of biological synthesized platinum nanoparticles using Ononidis radix extract on the cell lung carcinoma A549
Renata Dobrucka , Aleksandra Romaniuk-Drapała , Mariusz Kaczmarek
AbstractDue to the search for new methods for synthesizing nanomaterials, this work proposes the biological synthesis of platinum nanoparticles using Ononidis radix extract. The synthesized platinum nanoparticles were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier transform infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The examination conducted by means of Transmission Electron Microscopy showed the presence of spherical and hexagonal platinum nanoparticles. Atomic Force Microscopy indicated the presence of locally agglomerated nanoparticles whose size was about 4 nm. The study also examined the influence of platinum nanoparticles on human non-small cell lung carcinoma cells A549. It was found that the mortality of cells cultured together with platinum nanoparticles increased, and the proliferative activity of A549 cells decreased gradually over time in proportion to the increasing concentration of the test substance.
|Journal series||Biomedical Microdevices, ISSN 1387-2176, e-ISSN 1572-8781, (N/A 70 pkt)|
|Publication size in sheets||0.5|
|Keywords in Polish||nanocząstki, biosynteza, właściwości przeciwnowotworowe|
|Keywords in English||Platinum nanopartilces, Green synthesis, Anticancer activity|
|Score||= 70.0, 06-04-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2018 = 0.707; : 2018 = 2.327 (2) - 2018=2.528 (5)|
|Uwagi||First Online: 25 July 2019|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.