Evaluation of biological synthesized platinum nanoparticles using Ononidis radix extract on the cell lung carcinoma A549

Renata Dobrucka , Aleksandra Romaniuk-Drapała , Mariusz Kaczmarek

Abstract

Due to the search for new methods for synthesizing nanomaterials, this work proposes the biological synthesis of platinum nanoparticles using Ononidis radix extract. The synthesized platinum nanoparticles were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier transform infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The examination conducted by means of Transmission Electron Microscopy showed the presence of spherical and hexagonal platinum nanoparticles. Atomic Force Microscopy indicated the presence of locally agglomerated nanoparticles whose size was about 4 nm. The study also examined the influence of platinum nanoparticles on human non-small cell lung carcinoma cells A549. It was found that the mortality of cells cultured together with platinum nanoparticles increased, and the proliferative activity of A549 cells decreased gradually over time in proportion to the increasing concentration of the test substance.
Author Renata Dobrucka (WT / KTiEPP)
Renata Dobrucka,,
- Department of Industrial Products and Ecology
, Aleksandra Romaniuk-Drapała - Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Aleksandra Romaniuk-Drapała,,
-
, Mariusz Kaczmarek - Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Mariusz Kaczmarek,,
-
Journal seriesBiomedical Microdevices, ISSN 1387-2176, e-ISSN 1572-8781, (N/A 70 pkt)
Issue year2019
Vol21
Pages1-10
Publication size in sheets0.5
Keywords in Polishnanocząstki, biosynteza, właściwości przeciwnowotworowe
Keywords in EnglishPlatinum nanopartilces, Green synthesis, Anticancer activity
ASJC Classification1312 Molecular Biology; 2204 Biomedical Engineering
DOIDOI:10.1007/s10544-019-0424-7
URL https://link.springer.com/article/10.1007/s10544-019-0424-7
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 06-04-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.707; WoS Impact Factor: 2018 = 2.327 (2) - 2018=2.528 (5)
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UwagiFirst Online: 25 July 2019
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