The Effects of High Dietary Doses of Chromium(III) Complex with Propionic Acid on Nutritional and Selected Blood Indices in Healthy Female Rats

Halina Staniek , Zbigniew Krejpcio , Daria Wieczorek

Abstract

People taking dietary supplements are usually determined to lose weight, supplement nutrition or reduce the risk of illness and negative effects of their state of health. Chromium(III) supplementation influence body composition and mass, glucose and lipid metabolism and it enhance insulin action. This fact could be of general interest because diabetes mellitus is an increasing health problem in many countries. The study describes the effects of high dietary doses of chromium(III) complex with propionic acid [Cr3] (from 100 to 1000 mg Cr · kg−1 diet) on the organisms of healthy female rats, with special regard to overall nutritional, carbohydrate, lipid and blood biochemical and morphological and haematological indices. The study was carried out on 30 10-week-old female Wistar rats, which were divided into five equal groups (six animals in each): the control group and four groups of tested animals which had free access to the diet supplemented with 100, 200, 500 and 1000 mg Cr · kg−1 (equivalent of 10, 20, 50 and 100 mg Cr · kg body weight (b.w.) · day-1), given as [Cr3O(O2CCH2CH3)6(H2O)3]⋅NO3, also known as Cr3, for 4 weeks. There were no significant differences in body mass gains, feeding efficiency ratio, internal organ masses or blood serum glucose concentrations, except for some changes in the serum triglycerides concentration, which decreased in the rats that received 500 and 1000 mg Cr · kg−1 diet, as opposed to the group treated with 200 mg Cr · kg−1 diet. The dietary supplementation of Cr3 for 4 weeks at doses of 100 to 1000 mg Cr · kg−1 diet did not affect overall nutritional indices and most blood biochemical, morphological and haematological indices.
Author Halina Staniek - Uniwersytet Przyrodniczy w Poznaniu
Halina Staniek,,
-
, Zbigniew Krejpcio - Uniwersytet Przyrodniczy w Poznaniu
Zbigniew Krejpcio,,
-
, Daria Wieczorek (WT / KTiAI)
Daria Wieczorek,,
- Department of Technology and Instrumental Analysis
Journal seriesBiological Trace Element Research, ISSN 0163-4984, e-ISSN 1559-0720, (A 15 pkt)
Issue year2016
Vol171
No1
Pages192-200
Publication size in sheets0.5
Keywords in EnglishChromium(III) propionate complex, Supplementation rats, Dietary Doses of Chromium
ASJC Classification2704 Biochemistry, medical; 1604 Inorganic Chemistry; 1308 Clinical Biochemistry; 2700 General Medicine; 1303 Biochemistry; 2712 Endocrinology, Diabetes and Metabolism
DOIDOI:10.1007/s12011-015-0518-x
URL https://link.springer.com/article/10.1007%2Fs12011-015-0518-x
Languageen angielski
Score (nominal)15
ScoreMinisterial score = 15.0, 26-10-2019, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 26-10-2019, ArticleFromJournal
Publication indicators WoS Citations = 5; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.849; WoS Impact Factor: 2016 = 2.399 (2) - 2016=2.059 (5)
Citation count*8 (2020-08-03)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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