Synthesis, Surface and Antimicrobial Activity of New Lactose-Based Surfactants

Katarzyna Michocka , Katarzyna Staszak , Daniela Gwiazdowska , Daria Wieczorek


This work presents a synthesis method for new surfactants based on lactose. The compounds obtained belong to the homologous series of O-β-D-Galactopyranosyl-(1→4)-N-alkyl-(3-sulfopropyl)-Dglucosamine hydrochloride, containing 12 and 14 carbon atoms in the alkyl chain, and they may serve as an example of cationic surfactants. The newly synthesized compounds exhibit good surface properties, low value of CMC (Critical Micelle Concentration) and good wetting properties. These surfactants’ ability to produce foam is considerably higher than in the commercial surfactants. Moreover, antibacterial and fungistatic activity was carried out by well diffusion assay against the selected bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa), yeasts (Candida albicans) and filamentous fungi (Fusarium graminearum, F. avenaceum, F. oxysporum, F. culmorum, F. equiseti, Alternaria alternata and Botrytis cinerea). It was shown that the resulting quaternary salts significantly inhibit the growth of tested microorganisms. Antibacterial and fungistatic activity of the surfactant compounds varied depending on the species of bacteria or fungi. The results of antimicrobial activity of new lactose derivatives indicate that the compounds exhibit larger or similar antagonistic activity against tested bacteria and fungi than typical cationic surfactant cetylpyridinium chloride.
Author Katarzyna Michocka (WT / KTiAI)
Katarzyna Michocka,,
- Department of Technology and Instrumental Analysis
, Katarzyna Staszak - Politechnika Poznańska (PP)
Katarzyna Staszak,,
, Daniela Gwiazdowska (WT / KPPJ)
Daniela Gwiazdowska,,
- Department of Natural Science and Quality Assurance
, Daria Wieczorek (WT / KTiAI)
Daria Wieczorek,,
- Department of Technology and Instrumental Analysis
Journal seriesMolecules, ISSN 1420-3049, (N/A 100 pkt)
Issue year2019
Publication size in sheets0.7
Keywords in Polishsurfaktanty laktozowe, cmc, napięcie powierzchniowe, właściwości pianotwórcze, aktywność przeciwdrobnoustrojowa
Keywords in Englishlactose-based surfactants, O--D-Galactopyranosyl-(1,4)-N-alkyl-(3-sulfopropyl)-D -glucosamine hydrochloride, CMC, surface tension, foamability, antimicrobial activity
ASJC Classification1605 Organic Chemistry
Languageen angielski
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 09-04-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.146; WoS Impact Factor: 2018 = 3.06 (2) - 2018=3.38 (5)
Citation count*1 (2020-07-04)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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