Synthesis, Surface and Antimicrobial Activity of New Lactose-Based Surfactants
Katarzyna Michocka , Katarzyna Staszak , Daniela Gwiazdowska , Daria Wieczorek
AbstractThis work presents a synthesis method for new surfactants based on lactose. The compounds obtained belong to the homologous series of O-β-D-Galactopyranosyl-(1→4)-N-alkyl-(3-sulfopropyl)-Dglucosamine hydrochloride, containing 12 and 14 carbon atoms in the alkyl chain, and they may serve as an example of cationic surfactants. The newly synthesized compounds exhibit good surface properties, low value of CMC (Critical Micelle Concentration) and good wetting properties. These surfactants’ ability to produce foam is considerably higher than in the commercial surfactants. Moreover, antibacterial and fungistatic activity was carried out by well diffusion assay against the selected bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa), yeasts (Candida albicans) and filamentous fungi (Fusarium graminearum, F. avenaceum, F. oxysporum, F. culmorum, F. equiseti, Alternaria alternata and Botrytis cinerea). It was shown that the resulting quaternary salts significantly inhibit the growth of tested microorganisms. Antibacterial and fungistatic activity of the surfactant compounds varied depending on the species of bacteria or fungi. The results of antimicrobial activity of new lactose derivatives indicate that the compounds exhibit larger or similar antagonistic activity against tested bacteria and fungi than typical cationic surfactant cetylpyridinium chloride.
|Journal series||Molecules, ISSN 1420-3049, (N/A 100 pkt)|
|Publication size in sheets||0.7|
|Keywords in Polish||surfaktanty laktozowe, cmc, napięcie powierzchniowe, właściwości pianotwórcze, aktywność przeciwdrobnoustrojowa|
|Keywords in English||lactose-based surfactants, O--D-Galactopyranosyl-(1,4)-N-alkyl-(3-sulfopropyl)-D -glucosamine hydrochloride, CMC, surface tension, foamability, antimicrobial activity|
|Score||= 100.0, 09-04-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2017 = 1.146; : 2018 = 3.06 (2) - 2018=3.38 (5)|
|Citation count*||1 (2020-07-04)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.