Antimicrobial activity of organic–inorganic hybrid films based on gelatin and organomodified silicones

Patrycja Wojciechowska , Mariusz Tichoniuk , Daniela Gwiazdowska , Hieronim Maciejewski , Marek Nowicki

Abstract

Gelatin–siloxane hybrid films containing antimicrobial agents were prepared in the two‐step procedure. First, gelatin was chemically modified with organomodified silicones containing epoxy (S1) and both epoxy and fluoroalkyl groups (S2). Next, antimicrobial agents such as lysozyme, EDTA, and nisin, in various concentrations, were introduced into obtained hybrid solution, prior to solvent casting of the films. Antimicrobial activity of prepared samples, as well as neat gelatin and gelatin–siloxane hybrid as a reference, was investigated using a modified agar diffusion method against several bacterial strains (Aeromonas hydrophila, Bacillus subtilis, Escherichia coli) and opportunistic fungus (yeast species Candida albicans). Prepared gelatin–siloxane films were characterized using FT‐IR, thermal and SEM analysis. Mechanical properties and swelling behavior of the samples were also investigated. The influence of type and amount of organosilicon compound used for modification of gelatin, as well as type and concentration of applied active agent on antimicrobial activity, was determined. We observed higher antimicrobial activity for all synthesized gelatin–siloxane hybrids than for unmodified gelatin with lysozyme, nisin, and EDTA prepared as comparison. Moreover, samples obtained with siloxane containing fluoroalkyl groups (S2) showed higher resistance to microbial agents than hybrids with S1 siloxane. Hybrid films showed also better water stability than neat biopolymer.
Author Patrycja Wojciechowska (WT / KTiEPP)
Patrycja Wojciechowska,,
- Department of Industrial Products and Ecology
, Mariusz Tichoniuk (WT / KTiEPP)
Mariusz Tichoniuk,,
- Department of Industrial Products and Ecology
, Daniela Gwiazdowska (WT / KPPJ)
Daniela Gwiazdowska,,
- Department of Natural Science and Quality Assurance
, Hieronim Maciejewski - Adam Mickiewicz University (UAM)
Hieronim Maciejewski,,
-
, Marek Nowicki - Politechnika Poznańska (PP)
Marek Nowicki,,
-
Journal seriesAdvances in Polymer Technology, ISSN 0730-6679, (A 30 pkt)
Issue year2018
Vol37
No8
Pages2958-2970
Publication size in sheets0.6
Keywords in Englishsilicones, films, biopolymers, gelatin, antimicrobial
ASJC Classification1500 General Chemical Engineering; 1605 Organic Chemistry; 2507 Polymers and Plastics
DOIDOI:10.1002/adv.21967
URL https://doi.org/10.1002/adv.21967
Languageen angielski
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 18-03-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.835; WoS Impact Factor: 2018 = 2.663 (2) - 2018=1.986 (5)
Citation count*3 (2020-09-26)
Additional fields
UwagiFirst Online 25 March 2018
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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