Facile Synthesis of Sulfobetaine-Stabilized Cu2O Nanoparticles and Their Biomedical Potential

Marta J. Woźniak-Budych , Łucja Przysiecka , Barbara M. Maciejewska , Daria Wieczorek , Katarzyna Staszak , Marcin Jarek , Teofil Jesionowski , Stefan Jurga


A novel approach using a zwitterionic sulfobetaine-based surfactant for the synthesis of spherical copper oxide nanoparticles (Cu2O NPs) has been applied. For the first time, N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate has been used as stabilizer to control the size and morphology of Cu2O NPs. Several techniques, such as transmission electron microscopy (TEM), X-ray diffraction (XRD), and fluorescence spectroscopy, are used to investigate the size, structure, and optical properties of synthesized Cu2O nanocrystals. The results indicate that copper(I) oxide nanoparticles with size in the range of 2 to 45 nm and crystalline structure, exhibit intense yellow fluorescence (λem = 575 nm). Furthermore, the cytotoxicity studies show that sulfobetaine-stabilized copper oxide nanoparticles prompt inhibition of cancer cell proliferation in a concentration-dependent manner, however, the adverse effect on the normal cells has also been observed. The results indicate that the sulfobetaine-stabilized Cu2O, because of their unique properties, have a potential to be applied in medical fields, such as cancer therapy and bioimaging.
Author Marta J. Woźniak-Budych - Adam Mickiewicz University (UAM)
Marta J. Woźniak-Budych,,
, Łucja Przysiecka - University Adam Mickiewicz in Poznań
Łucja Przysiecka,,
, Barbara M. Maciejewska - University Adam Mickiewicz in Poznań
Barbara M. Maciejewska,,
, Daria Wieczorek (WT / KTiAI)
Daria Wieczorek,,
- Department of Technology and Instrumental Analysis
, Katarzyna Staszak - Politechnika Poznańska
Katarzyna Staszak,,
, Marcin Jarek - University Adam Mickiewicz in Poznań
Marcin Jarek,,
, Teofil Jesionowski - Politechnika Poznańska (PP), MNiSW [80]
Teofil Jesionowski,,
, Stefan Jurga - University Adam Mickiewicz in Poznań
Stefan Jurga,,
Journal seriesACS Biomaterials Science & Engineering, [ACS Biomaterial Science and Engineering], ISSN 2373-9878, (0 pkt)
Issue year2017
Publication size in sheets0.55
Keywords in Englishcopper oxide nanoparticles, sulfobetaine, zwitterionic surfactant, flurorescence properties
ASJC Classification2204 Biomedical Engineering; 2502 Biomaterials
URL https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.7b00465
Languageen angielski
Score (nominal)15
Score sourcejournalIndex
ScoreMinisterial score = 15.0, 19-03-2020, ArticleFromJournal
Publication indicators WoS Citations = 2; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.057; WoS Impact Factor: 2017 = 4.432 (2) - 2017=4.435 (5)
Citation count*6 (2020-09-22)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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