How taste works: cells, receptors and gustatory perception

Dariusz Kikut-Ligaj , Joanna Trzcielińska-Lorych

Abstract

AbstractThe sensitivity of taste in mammals varies due to quantitative and qualitative differences in the structure of the taste perception organs. Gustatory perception is made possible by the peripheral chemosensory organs, i.e., the taste buds, which are distributed in the epithelium of the taste papillae of the palate, tongue, epiglottis, throat and larynx. Each taste bud consists of a community of ~100 cells that process and integrate taste information with metabolic needs. Mammalian taste buds are contained in circumvallate, fungiform and foliate papillae and react to sweet, salty, sour, bitter and umami stimuli. The sensitivity of the taste buds for individual taste stimuli varies extensively and depends on the type of papillae and the part of the oral cavity in which they are located. There are at least three different cell types found in mammalian taste buds: type I cells, receptor (type II) cells and presynaptic (type III) cells. This review focuses on the biophysiological mechanisms of action of the various taste stimuli in humans. Currently, the best-characterized proteins are the receptors (GPCR). In addition, the activation of bitter, sweet and umami tastes are relatively well known, but the activation of salty and sour tastes has yet to be clearly explained.
Author Dariusz Kikut-Ligaj (WT / KPPJ)
Dariusz Kikut-Ligaj,,
- Department of Natural Science and Quality Assurance
, Joanna Trzcielińska-Lorych - Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Joanna Trzcielińska-Lorych,,
-
Journal seriesCellular & Molecular Biology Letters, ISSN 1425-8153, (A 15 pkt)
Issue year2015
Vol20
No5
Pages 699 - 716
Publication size in sheets0.85
Keywords in Polishbrodawki smakowe, kubki smakowe, postrzeganie smaku, podstawowe jakości smakowe, rodzaje komórek zlokalizowanych w kubkach smakowych, aktywacja receptorów smakowych, nabłonkowe kanały sodowe, ENaC, receptory smaku gorzkiego, słodkiego i umami, TASR, TAS2R zlokalizowane poza jamą ustną, kanał modulatora homeostazy wapnia 1, CALHM1
Keywords in EnglishTaste papillae, Taste buds, Taste perception, Basic taste qualities, Types of cells located in the taste buds, Activation of taste receptor cells, Epithelial sodium channels, ENaC, Bitter, Sweet and umami taste receptors, TASRs, Extra-oral tissue TAS2Rs, Calcium homeostasis modulator 1 channel, CALHM1
ASJC Classification1303 Biochemistry; 1307 Cell Biology; 1312 Molecular Biology
DOIDOI:10.1515/cmble-2015-0042
Languageen angielski
Score (nominal)15
Score sourcejournalList
ScoreMinisterial score = 15.0, 10-01-2020, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 10-01-2020, ArticleFromJournal
Publication indicators WoS Citations = 7; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 0.751; WoS Impact Factor: 2015 = 1.753 (2) - 2015=1.681 (5)
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