How taste works: cells, receptors and gustatory perception
Dariusz Kikut-Ligaj , Joanna Trzcielińska-Lorych
AbstractAbstractThe sensitivity of taste in mammals varies due to quantitative and qualitative differences in the structure of the taste perception organs. Gustatory perception is made possible by the peripheral chemosensory organs, i.e., the taste buds, which are distributed in the epithelium of the taste papillae of the palate, tongue, epiglottis, throat and larynx. Each taste bud consists of a community of ~100 cells that process and integrate taste information with metabolic needs. Mammalian taste buds are contained in circumvallate, fungiform and foliate papillae and react to sweet, salty, sour, bitter and umami stimuli. The sensitivity of the taste buds for individual taste stimuli varies extensively and depends on the type of papillae and the part of the oral cavity in which they are located. There are at least three different cell types found in mammalian taste buds: type I cells, receptor (type II) cells and presynaptic (type III) cells. This review focuses on the biophysiological mechanisms of action of the various taste stimuli in humans. Currently, the best-characterized proteins are the receptors (GPCR). In addition, the activation of bitter, sweet and umami tastes are relatively well known, but the activation of salty and sour tastes has yet to be clearly explained.
|Journal series||Cellular & Molecular Biology Letters, ISSN 1425-8153, (A 15 pkt)|
|Pages||699 - 716|
|Publication size in sheets||0.85|
|Keywords in Polish||brodawki smakowe, kubki smakowe, postrzeganie smaku, podstawowe jakości smakowe, rodzaje komórek zlokalizowanych w kubkach smakowych, aktywacja receptorów smakowych, nabłonkowe kanały sodowe, ENaC, receptory smaku gorzkiego, słodkiego i umami, TASR, TAS2R zlokalizowane poza jamą ustną, kanał modulatora homeostazy wapnia 1, CALHM1|
|Keywords in English||Taste papillae, Taste buds, Taste perception, Basic taste qualities, Types of cells located in the taste buds, Activation of taste receptor cells, Epithelial sodium channels, ENaC, Bitter, Sweet and umami taste receptors, TASRs, Extra-oral tissue TAS2Rs, Calcium homeostasis modulator 1 channel, CALHM1|
|ASJC Classification||; ;|
|Score|| = 15.0, 10-01-2020, ArticleFromJournal|
= 15.0, 10-01-2020, ArticleFromJournal
|Publication indicators||= 7; : 2015 = 0.751; : 2015 = 1.753 (2) - 2015=1.681 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.