Chromium(III) Glycinate Complex Supplementation Improves the Blood Glucose Level and Attenuates the Tissular Copper to Zinc Ratio in Rats with Mild Hyperglycaemia
Ewelina Król , Zbigniew Krejpcio , Monika Okulicz , Hanna Śmigielska
AbstractThe aim of the study was to evaluate the hypoglycaemic potential of supplementary Cr in the form of chromium(III) glycinate (CrGly) in the diabetic model of rats. The experiment was conducted on 40 maleWistar rats, of which 30 were made diabetic by injection of a single dose of streptozotocin (55 mg/kg b.m.), while the remaining 10 rats served as the healthy control. After inducing hyperglycaemia, 2 groups of diabetic rats (10 rats each) were supplemented with Cr either as CrGly or chromium(III) picolinate (CrPic) given orally at a dose of 10 mg/kg diet (about 0.75 mg Cr/kg b.m.) with adequate AIN-93M diet for 7 weeks. At the termination of experiment, all animals were sacrificed to collect blood and internal organs for biochemical assays. Blood biochemical indices and tissular trace element contents (Fe, Zn, Cu, Cr) were measured and compared with the values of the untreated groups. It was found that CrGly significantly decreased blood glucose, total cholesterol, HDL cholesterol and triacylglycerol levels more efficiently than CrPic. Furthermore, both Cr compounds normalized disturbed the serum, renal and cardiac molar Cu/Zn ratio, as well as restored the kidney Zn and Cu levels in rats with hyperglycaemia. Supplementary Cr did not increase the tissular Cr levels in diabetic rats. The study confirmed the hypoglycaemic potential of CrGly in the diabetic model of rats.
|Journal series||Biological Trace Element Research, ISSN 0163-4984, e-ISSN 1559-0720, (N/A 70 pkt)|
|Publication size in sheets||0.5|
|Keywords in Polish||kompleks glicynianu chromu(III) , Pikolinian Chromu(III), suplemantacja, hiperglikemia|
|Keywords in English||Chromium(III) glycinate complex Chromium(III) picolinate Supplementation Hyperglycaemia Diabetic rats|
|ASJC Classification||; ; ; ; ;|
|Score||= 70.0, 03-05-2020, ArticleFromJournal|
|Publication indicators||= 1; : 2018 = 0.882; : 2018 = 2.431 (2) - 2018=2.406 (5)|
|Citation count*||2 (2020-06-23)|
|Uwagi||First online: 02 March 2019|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.