Chromium(III) Glycinate Complex Supplementation Improves the Blood Glucose Level and Attenuates the Tissular Copper to Zinc Ratio in Rats with Mild Hyperglycaemia

Ewelina Król , Zbigniew Krejpcio , Monika Okulicz , Hanna Śmigielska

Abstract

The aim of the study was to evaluate the hypoglycaemic potential of supplementary Cr in the form of chromium(III) glycinate (CrGly) in the diabetic model of rats. The experiment was conducted on 40 maleWistar rats, of which 30 were made diabetic by injection of a single dose of streptozotocin (55 mg/kg b.m.), while the remaining 10 rats served as the healthy control. After inducing hyperglycaemia, 2 groups of diabetic rats (10 rats each) were supplemented with Cr either as CrGly or chromium(III) picolinate (CrPic) given orally at a dose of 10 mg/kg diet (about 0.75 mg Cr/kg b.m.) with adequate AIN-93M diet for 7 weeks. At the termination of experiment, all animals were sacrificed to collect blood and internal organs for biochemical assays. Blood biochemical indices and tissular trace element contents (Fe, Zn, Cu, Cr) were measured and compared with the values of the untreated groups. It was found that CrGly significantly decreased blood glucose, total cholesterol, HDL cholesterol and triacylglycerol levels more efficiently than CrPic. Furthermore, both Cr compounds normalized disturbed the serum, renal and cardiac molar Cu/Zn ratio, as well as restored the kidney Zn and Cu levels in rats with hyperglycaemia. Supplementary Cr did not increase the tissular Cr levels in diabetic rats. The study confirmed the hypoglycaemic potential of CrGly in the diabetic model of rats.
Author Ewelina Król - Uniwersytet Przyrodniczy w Poznaniu, MNiSW [80]
Ewelina Król,,
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, Zbigniew Krejpcio - Uniwersytet Przyrodniczy w Poznaniu
Zbigniew Krejpcio,,
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, Monika Okulicz - Uniwersytet Przyrodniczy w Poznaniu
Monika Okulicz,,
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, Hanna Śmigielska (WT / KPPJ)
Hanna Śmigielska,,
- Department of Natural Science and Quality Assurance
Journal seriesBiological Trace Element Research, ISSN 0163-4984, e-ISSN 1559-0720, (N/A 70 pkt)
Issue year2020
Vol193
No1
Pages185-194
Publication size in sheets0.5
Keywords in Polishkompleks glicynianu chromu(III) , Pikolinian Chromu(III), suplemantacja, hiperglikemia
Keywords in EnglishChromium(III) glycinate complex Chromium(III) picolinate Supplementation Hyperglycaemia Diabetic rats
ASJC Classification2700 General Medicine; 2704 Biochemistry, medical; 2712 Endocrinology, Diabetes and Metabolism; 1303 Biochemistry; 1308 Clinical Biochemistry; 1604 Inorganic Chemistry
DOIDOI:10.1007/s12011-019-01686-7
URL https://link.springer.com/article/10.1007%2Fs12011-019-01686-7
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 03-05-2020, ArticleFromJournal
Publication indicators WoS Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.882; WoS Impact Factor: 2018 = 2.431 (2) - 2018=2.406 (5)
Citation count*2 (2020-06-23)
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UwagiFirst online: 02 March 2019
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